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Blood or sputum eosinophils to guide asthma therapy?
Manali Mukherjee, Parameswaran Naire
Lancet Respir Med. 2015 Nov;3(11):824-5. doi: 10.1016/S2213-2600(15)00419-1. Epub 2015 Oct 19
Infiltration of airways by eosinophils and their degranulation in patients with asthma have been recognised since the late 19th century when Paul Ehrlich described methods for eosinophil staining. Not long after this, Gollasch recorded the association between eosinophils in sputum and asthma severity. Improvements in methods to disperse sputum and to obtain cytospins helped to quantitate eosinophils and to use counts to improve clinical care of patients with asthma. This work has improved our understanding of the pathogenesis, pathophysiology, and treatment of airway diseases.