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The role of adherence to ICS in the relationship between blood eosinophilia and asthma control.
Professor Joan Soriano discusses the subpopulation for which adherence to ICS is not enough to control exacerbations of asthma.
Prof Soriano gives a brief update on research data involving 6000 patients with weekly, nightly and daily symptoms at Stage III or IV of the gina classification. They showed that even when patients are using inhaled corticosteroids with reasonably good adherence, a fraction of these will still have exacerbations and are uncontrolled. These exacerbations were seen in about 1:4 to 1:5 patients with normal eosinophils (<400 mm3) and with hyper-eosinophilia (>400 mm3). In summary, even in asthma patients with good adherence to inhaled corticosteroids, there is a subset of about 20-25% who still suffer exacerbations and are uncontrolled.